Table 3.

Univariate analyses

Parameter	n = 386	Overall survival since histological diagnosis
		Median (months)	P value	Hazard ratio	95% CI
Tumor volume			.002
<100cc	335	249		1 (ref)
≥100cc	51	142		2.31	1.27–3.96
Spontaneous VDE			<.001
<8 mm/year	320	249		1 (ref)
≥8 mm/year	66	91		3.96	2.25–6.66
Spontaneous VDE			<.001
<4 mm/year	196	253		1 (ref)
4 and <8 mm/year	126	210		1.33	0.59–1.50
8 and <12 mm/year	26	91		3.41	1.19–4.99
12 and >mm/year	40	75		5.91	2.28–8.82
First-line surgical resection			.054
No	196	210		1 (ref)
Yes	190	249		0.74	0.47–1.15
Parameter	n = 380	Malignant free survival since histological diagnosis
Corpus callosum involvement			.003
No	330	95		1 (ref)
Yes	50	59		1.73	1.16–2.50
Contrast enhancement			.014
No	317	93		1 (ref)
Faint and patchy	51	89		1.46	1.11–1.88
Nodular-like	12	39		2.19	1.22–3.72
Tumor volume			.001
<100cc	330	93		1 (ref)
≥100cc	50	48		1.90	1.26–2.76
Spontaneous VDE			<.001
<8 mm/year	316	103		1 (ref)
≥8 mm/year	64	39		3.50	2.44–4.94
Spontaneous VDE			<.001
<4 mm/year	195	117		1 (ref)
4 and <8 mm/year	123	83		1.43	0.78–1.91
8 and <12 mm/year	25	60		2.71	1.15–3.16
12 and >mm/year	39	31		6.50	3.23–7.92
First-line surgical resection			<.001
No	192	68		1 (ref)
Yes	188	127		0.42	0.31–0.57
Extent of surgical resection			<.001
Biopsy	192	68		1 (ref)
Partial removal	86	103		0.59	0.22–0.96
Subtotal removal	64	133		0.39	0.14–0.78
Total removal	38	.		0.09	0.003–0.17