Table 4.
Multivariate analyses
| Parameter, n = 386 | Overall survival since histological diagnosis |
||
|---|---|---|---|
| P value | Hazard ratio | 95% CI | |
| Tumor volume ≥100 cc | .001 | 2.92 | 1.54–5.16 |
| Spontaneous VDE ≥ 8 mm/year | <.001 | 4.62 | 2.58–7.97 |
| Parameter, n = 380 | Malignant free survival since histological diagnosis | ||
| Tumor volume ≥100 cc | .008 | 1.76 | 1.16–2.60 |
| Spontaneous VDE ≥ 8 mm/year | <.001 | 3.87 | 2.67–5.52 |
| Contrast enhancement | .011 | 1.44 | 1.09–1.87 |
| First line surgical resection | <.001 | 0.44 | 0.32–0.59 |
| Parameter, n = 170 | Overall survival since histological diagnosis | ||
| 1p19q codeletion | .040 | 0.45 | 0.21–0.91 |
| Spontaneous VDE ≥ 8 mm/year | <.001 | 6.25 | 2.80–13.62 |
| Parameter, n = 197 | Malignant free survival since histological diagnosis | ||
| 1p19q codeletion | .021 | 0.59 | 0.37–0.92 |
| Tumor volume ≥100 cc | .031 | 1.87 | 1.06–3.29 |
| Spontaneous VDE ≥ 8 mm/year | <.001 | 3.27 | 1.92–5.53 |
| Contrast enhancement | .049 | 1.58 | 1.01–2.51 |
| First line surgical resection | <.001 | 0.33 | 0.22–0.51 |
Multivariate analyses in the whole population (n = 386 for overall survival, n = 380 for malignant progression-free survival) and in the subgroup with available 1p19q codeletion status (n = 170 for overall survival, n = 197 for malignant progression-free survival).