Table 3.
Combined anatomic, diffusion, and perfusion imaging21 and spectroscopic imaging predictors
| OS | PFS/PFS6 | ||
|---|---|---|---|
| Baseline | MRI | T2ALL vol, NEL vol | T2ALL median nPH*/nCBV/nRF |
| NEL median nPH/nCBV/nRF | |||
| MRSI | T2L*/CNI2/CNI2T/CNI3 sum nLL | CNI3 median NAA/Cho | |
| F2mo | MRI | T2ALL vol,* NEL vol,* CEL vol* | T2ALL/NEL median nCBV |
| MRSI | T2L median nLL (+ max nCr), CNI2*/CNI2T**/CNI3* max nLL, CNI2T vol* | CNI2 vol | |
| CNI2 max CNI | |||
| CNI2T/CNI3 median CNI | |||
| T2L median NAA/Cho | |||
| Delta | MRI | None | T2ALL/NEL 90th nRF |
| MRSI | CNI3 max nLL,* CNI2T vol* | None |
Abbreviations: NEL, non-enhancing lesion; nPH, normalized peak height; nCBV, normalized cerebral blood volumes; nRF, normalized recirculation factor. *P < .01; **P < .001. All the tests were adjusted by age and field strength. Italics represent the parameters that had HR or OR < 1.