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. 2013 Feb 26;15(5):562–577. doi: 10.1093/neuonc/not005

Fig. 2.

Fig. 2.

P4HB overexpressed in tumor specimens from patients with recurrence due to acquired TMZ resistance. (A) Representative pictures of immunohistochemical staining of P4HB in human GBM specimens. P4HB stained intensely in (ii) recurrent (R) GBM paraffin sections, but not in (i) treatment naive (TN) sections from patient #1 (Pat. #1) who developed recurrence after 5 cycles of treatment. Similarly, P4HB was stained positively in (iv) recurrent (R) GBM paraffin sections, but not in (iii) treatment naive (TN) sections from patient #2 (Pat. #2). (v) No staining was observed in normal brain paraffin sections obtained from cadaver donor as control. Scale bar, 10 µm. Original magnification: 100×; 400× (insets). (B) Western blot shows P4HB was highly expressed in tissues from patients developed TMZ resistance after a favorable treatment response.