Table 6.

GRADE profile 2 assessment at follow-up

Number of studies	Design	Results	Limitations	Inconsistency	Indirectness	Imprecision	Other considerations	Quality
Effectiveness of assessment of severity
3: Chang et al, 201213 Malpass et al, 201018 Moore et al, 201220 Yeung et al, 201222	Quasi-randomised controlled trial and observational	Monthly feedback of severity scores to practitioners was associated with increased chances of remission and response to treatment. However, feedback was not associated with an increase in medication change, although discontinuation of medication was approximately half that of no monthly feedback. However, in another study, severity scores at follow-up were also associated with increased rates of management changes. Practitioners reported that they found the feedback useful and patients used the scores as a way to measure their own treatment response and recovery process	No serious limitations	Some serious inconsistencya	No serious indirectness	Some serious imprecisionb	None	LOWC

^aSpecifically around the impact on changes in management.

^bWhere reported, some CIs were wide; however, this has not been downgraded, owing to the heterogeneity of results.

^cInitial level of MODERATE, owing to quasi randomised controlled trial study.