Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Global symptom improvement
RCT	27 people with chronic pancreatitis, 9 men, mean age 51 years, faecal fat values greater than or equal to 10 g/day and/or a fat absorption <80% In review	Mean difference in patient-scored Clinical Global Impression Disease Symptoms Scale (CGIDS) from baseline 2 weeks –0.3 with pancreatin (4 capsules at meal times and 2 with snacks) +0.4 with placebo	P = 0.06		Not significant
RCT	27 people with chronic pancreatitis, 9 men, mean age 51 years, faecal fat values greater than or equal to 10 g/day and/or a fat absorption <80% In review	Improvement in investigator-scored CGIDS from baseline 2 weeks –0.3 with pancreatin (4 capsules at meal times and 2 with snacks) +0.4 with placebo	P = 0.04	Effect size not calculated	pancreatin