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. 2012 Sep 26;75(5):1321–1327. doi: 10.1111/j.1365-2125.2012.04470.x

Table 2.

Pharmacokinetic parameters

Group R Group RE Difference group R vs. RE, (95% CI)
Cmax (μg ml−1) 2.81 (0.94) (1.94–3.82) 2.16 (0.21) (1.68–2.29) 0.65 (−0.23, 1.53)
tmax (h) 1.17 (0.30) (0.43–1.26) 1.67 (0.94) (1.25–3.35) −0.50 (−1.40, 0.40)
Cumax (μg ml−1) 0.16 (0.08) (0.07–0.30) 0.12 (0.04) (0.05–0.17) 0.04 (−0.04, 0.12)
AUC (μg ml−1 h) 28.35 (5.92) (22.49–39.23) 29.12 (7.34) (19.83–41.08) −0.77 (−9.35, 7.81)
t1/2 (h) 6.82 (2.26) (4.71–9.73) 5.48 (1.69) (3.02–8.07) 1.34 (−1.23, 3.91)

Groups as defined in Table 1. Values are mean (SD) (range). Cmax = maximum total ropivacaine concentration; tmax = time to Cmax; Cumax = maximum free ropivacaine concentration; AUC = area under the serum concentration–time curve from time zero to infinity; t1/2 = elimination half-life.