Table 3.
Genotype frequencies and univariate linear regression results
| Gene/SNP | Genotype [% (n)] | P value | |||
|---|---|---|---|---|---|
| AA | Aa | aa | Component 1 (residual pain) | Component 2 (central side-effects) | |
| OPRM1 | |||||
| rs6912029 | 0.91 (226) | 0.09 (23) | 0.0 (0) | 0.414 | 0.737 |
| rs1799971 | 0.74 (183) | 0.23 (58) | 0.03 (8) | 0.921 | 0.134 |
| rs589046 | 0.53 (128) | 0.41 (100) | 0.06 (15) | 0.338 | 0.299 |
| rs563649 | 0.81 (197) | 0.17 (41) | 0.02 (5) | 0.629 | 0.267 |
| rs9479757 | 0.01 (2) | 0.2 (49) | 0.79 (198) | 0.011 | 0.412 |
| rs2075572 | 0.34 (83) | 0.48 (118) | 0.19 (47) | 0.963 | 0.007 |
| rs533586 | 0.46 (112) | 0.43 (104) | 0.11 (27) | 0.47 | 0.02 |
| OPRK1 | |||||
| rs10504151 | 0.8 (196) | 0.18 (43) | 0.02 (5) | 0.628 | 0.123 |
| rs7836120 | 0.68 (167) | 0.28 (67) | 0.04 (10) | 0.299 | 0.977 |
| rs6473799 | 0.6 (146) | 0.36 (87) | 0.04 (11) | 0.39 | 0.179 |
| rs1365098 | 0.48 (116) | 0.42 (104) | 0.1 (24) | 0.209 | 0.499 |
| rs7016778 | 0.73 (178) | 0.26 (64) | 0.01 (2) | 0.254 | 0.429 |
| rs7824175 | 0.8 (196) | 0.18 (44) | 0.02 (4) | 0.012 | 0.487 |
| rs16918875 | 0.844 (206) | 0.15 (37) | 0.004 (1) | 0.319 | 0.307 |
| rs963549 | 0.67 (164) | 0.29 (71) | 0.04 (9) | 0.056 | 0.69 |
| OPRD1 | |||||
| rs1042114 | 0.72 (176) | 0.26 (63) | 0.02 (4) | 0.687 | 0.668 |
| rs533123 | 0.63 (152) | 0.32 (78) | 0.05 (13) | 0.573 | 0.798 |
| rs419335 | 0.5 (121) | 0.42 (101) | 0.08 (21) | 0.141 | 0.259 |
| rs2236857 | 0.58 (142) | 0.35 (86) | 0.06 (15) | 0.35 | 0.249 |
| rs2234918 | 0.33 (82) | 0.49 (118) | 0.18 (43) | 0.89 | 0.861 |
DNA was available for the following genes/SNPs: OPRM1 rs6912029, rs1799971, rs9479757 and rs9479757, n = 249; OPRM1 rs589046, rs563649 and rs533586, n = 243; OPRK1, n = 244; and OPRD1, n = 243. SNP, single nucleotide polymorphism.