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. 2013 Apr 1;123(5):2064–2077. doi: 10.1172/JCI64375

Figure 7. MKP-5 deficiency increases the expression of cyclin D3 in SCs.

Figure 7

Eight-week-old male mouse hind limb muscles were damaged by CTX, and 48 hours later muscles were dissected and digested to isolate cells for flow cytometry. Gated (PAX7+) cells (A) were analyzed for cyclin D1 (B), cyclin D2 (C), cyclin D3 (D), CDK4 (E), and CDK6 (F). No stain control (red); Mkp5+/+ (blue); Mkp5–/– (green). Data represent 3 independent experiments with 2 mice from each genotype in each independent experiment. Protein content was evaluated by measuring the median fluorescence intensity and expressed as fold change relative to Mkp5+/+. **P < 0.01 compared with Mkp5+/+ mice. NS, not statistically significant.