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. 2013 Apr 15;123(5):2268–2286. doi: 10.1172/JCI65364

Figure 13. Spinal blockade of IL-18 and IL-18R reverses mechanical and thermal hypersensitivity induced by CCI and i.t.

Figure 13

WNT agonist, respectively, in rats. (A and B) CCI-induced mechanical allodynia (A) and thermal hyperalgesia (B). (C and D) WNT agonist–induced mechanical allodynia (C) and thermal hyperalgesia (D). Drug doses (i.t., in a volume of 20 μl): IL-18 antagonist IL-18BP (1 μg); IL-18R antibody (anti–IL-18R, 1 μg); and WNT agonist (40 μM). Arrows indicate the drug administrations. Eight rats were included in each group. (A–D) Two-way ANOVA with an individual Student’s t test were used. *P < 0.05, **P < 0.01 versus WNT agonist + saline, respectively. Black triangles indicate CCI surgery (A and B).