Figure 1. CD148-deficient mice are protected from AHR in the OVA mouse model of allergic airway disease and have decreased baseline pulmonary resistance.

(A) Pulmonary resistance measurements in WT and CD148-deficient (Ptprj^TM–/TM–) mice following immunization and intranasal challenge with OVA or saline in C57BL/6 mice (A) or BALB/c mice (B). Data are the mean ± SEM (n = 9–13 animals per group). Statistical significance determined by 2-way ANOVA. *P < 0.05, ***P < 0.001 in the WT versus Ptprj^TM–/TM– OVA group; ^##P < 0.01, ^###P < 0.001 comparing the highest dose of ACh in the WT saline group with the Ptprj^TM–/TM– saline group.