Figure 4. Developmentally regulated chemokine receptor expression and migration in human thymocytes.

(A and B) Relative levels of (A) CXCR4 and (B) CCR7 expression on the indicated gated populations of human fetal thymocytes, as assessed by flow cytometry. (C–E) Relative migration of human thymocyte populations toward mouse and human chemokines, as assessed by transwell assay. Migration was normalized to no-chemokine controls (dashed red lines). Experiments were performed twice with similar results; a representative experiment is shown.