Table 3.
Acute and late responding normal tissue biological effective dose (BED) score results (0.0–10.0) used to compare the predicted benefits of 11 different fractionation schedules used during hypoxic tumour simulations, with onset of accelerated repopulation (AR) and reoxygenation (ROx) modelled at 0 weeks, 2 weeks or not at all
| Acute normal tissue effects: BED formula—Tk=7 days, α=0.35 Gy−1, α/β=10 Gy, Tp=2.5 days | |||||||||||||
| Tumour type | Schedule number | Dose/fraction of radiotherapy | No AR, no ROx | AR (0 weeks) | AR (2 weeks) | ROx (0 weeks) | ROx (2 weeks) | ROx (0 weeks)+AR (0 weeks) | ROx (2 weeks)+AR (0 weeks) | ROx (0 weeks)+AR (2 weeks) | ROx (2 weeks)+ AR (2 weeks) | Summed BED scores | Summed BED order |
| Hypoxic tumours | 1 | 2.0 | 3.0 | 3.2 | 3.6 | 3.0 | 2.6 | 1.0 | 2.3 | 1.9 | 2.7 | 23.3 | 4 |
| 2 | 1.2 | 3.5 | 1.2 | 1.0 | 3.7 | 3.4 | 0.0 | 0.9 | 1.8 | 0.2 | 15.8 | 3 | |
| 3 | 1.1 | 2.2 | 0.1 | 1.0 | 2.8 | 1.7 | 0.7 | 0.1 | 0.0 | 0.8 | 9.4 | 2 | |
| 4 | 2.0 | 10.0 | 10.0 | 10.0 | 9.9 | 9.2 | 10.0 | 10.0 | 10.0 | 10.0 | 89.2 | 11 | |
| 5 | 2.0 | 4.8 | 3.7 | 3.7 | 5.0 | 4.5 | 3.1 | 3.2 | 3.7 | 3.7 | 35.3 | 6 | |
| 6 | 1.8 | 7.2 | 3.8 | 4.2 | 7.7 | 7.5 | 4.5 | 5.7 | 3.8 | 5.0 | 49.4 | 8 | |
| 7 | 1.5 | 9.7 | 4.5 | 5.6 | 10.0 | 10.0 | 3.3 | 8.1 | 5.9 | 8.2 | 65.3 | 10 | |
| 8 | 1.8 | 4.0 | 3.7 | 3.6 | 4.5 | 4.1 | 2.7 | 3.3 | 4.3 | 3.4 | 33.7 | 5 | |
| 9 | 1.5 | 8.8 | 5.8 | 4.7 | 8.4 | 7.7 | 7.9 | 7.4 | 4.3 | 5.0 | 60.2 | 9 | |
| 10 | 2.0 | 6.5 | 3.9 | 4.6 | 6.1 | 6.0 | 3.7 | 4.0 | 4.6 | 4.9 | 44.3 | 7 | |
| 11 | 1.2 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.8 | 0.0 | 0.4 | 0.0 | 1.2 | 1 | |
| Late normal tissue effects: BED formula—α/β=3 Gy | |||||||||||||
| Tumour type | Schedule number | Dose/fraction of radiotherapy | No AR, no ROx | AR (0 weeks) | AR (2 weeks) | ROx (0 weeks) | ROx (2 weeks) | ROx (0 weeks)+ AR(0 weeks) | ROx (2 weeks)+ AR (0 weeks) | ROx (0 weeks)+ AR (2 weeks) | ROx (2 weeks)+ AR (2 weeks) | Summed BED scores | Summed BED order |
| Hypoxic tumours | 1 | 2.0 | 7.1 | 10.0 | 10.0 | 8.4 | 8.2 | 10.0 | 10.0 | 10.0 | 10.0 | 83.7 | 11 |
| 2 | 1.2 | 1.9 | 2.6 | 0.9 | 0.7 | 3.2 | 3.8 | 0.2 | 3.4 | 0.6 | 17.0 | 2 | |
| 3 | 1.1 | 0.0 | 2.3 | 2.0 | 0.0 | 0.0 | 5.9 | 0.7 | 1.9 | 2.9 | 15.8 | 1 | |
| 4 | 2.0 | 10.0 | 7.9 | 7.7 | 10.0 | 10.0 | 8.2 | 6.3 | 9.0 | 6.6 | 75.6 | 10 | |
| 5 | 2.0 | 7.6 | 7.2 | 6.4 | 9.3 | 8.7 | 8.8 | 6.2 | 8.6 | 7.1 | 69.9 | 9 | |
| 6 | 1.8 | 6.2 | 2.6 | 2.1 | 6.7 | 8.5 | 4.8 | 2.6 | 2.2 | 2.8 | 38.5 | 5 | |
| 7 | 1.5 | 5.2 | 0.0 | 0.0 | 3.7 | 7.1 | 0.0 | 0.0 | 0.3 | 1.5 | 17.8 | 3 | |
| 8 | 1.8 | 5.0 | 5.7 | 5.0 | 7.9 | 7.4 | 7.2 | 4.7 | 8.7 | 5.8 | 57.4 | 7 | |
| 9 | 1.5 | 6.0 | 2.6 | 0.5 | 3.0 | 4.9 | 5.3 | 1.4 | 0.0 | 0.0 | 23.5 | 4 | |
| 10 | 2.0 | 9.2 | 5.4 | 5.5 | 8.2 | 9.6 | 7.1 | 4.3 | 7.2 | 6.2 | 62.8 | 8 | |
| 11 | 1.2 | 0.1 | 4.7 | 3.6 | 0.3 | 2.1 | 9.3 | 5.0 | 7.7 | 6.0 | 38.9 | 6 | |
Tk, repopulation kick-off time; Tp, potential doubling time.
A high score indicates a non-beneficial schedule (high toxicity—italics), an intermediate score represents a mid-range schedule (intermediate toxicity—bold) and a low score indicates a beneficial schedule (low toxicity—bold italic). The summed BED scores are added per schedule, with the underlined text representing the schedule with the lowest and highest values.