Table 2.
Percent inhibiton values of plants crude extracts on three human cancer cell lines at 20 and 200 μg/ml concentrations
|
Species |
T-549 |
BT-20 |
PC-3 |
|||
|---|---|---|---|---|---|---|
| 20 μg/ml | 200 μg/ml | 20 μg/ml | 200 μg/ml | 20 μg/ml | 200 μg/ml | |
| Acanthus montanus |
7 ± 5.01 |
10 ± 3.45 |
Nd |
27 ± 8.38* |
Nd |
<5 |
| Allanblackia floribunda |
66 ± 6.51* |
96 ± 3.48* |
21 ± 4.55 |
80 ± 5.38* |
13 ± 0.58 |
92 ± 5.29* |
| Amaranthus spinosus |
16 ± 3.86 |
<5 |
8 ± 1.72 |
32 ± 8.14 |
Nd |
Nd |
| Bidens pilosa |
23 ± 9.50 |
97 ± 1.63* |
Nd |
93 ± 1.73* |
35 ± 1.08 |
95 ± 1.53 |
| Bryophyllum pinnatum |
24 ± 6.08 |
96 ± 1.68* |
Nd |
81 ± 6.51* |
Nd |
95 ± 1.62* |
| Byrsocarpus coccineus Bark |
20 ± 2.51 |
100 |
Nd |
93 ± 2.66* |
Nd |
97 ± 6.15* |
| Leaves |
54 ± 1.76 |
100 |
Nd |
100 |
Nd |
100 |
| Cajanus cajan |
9 ± 1.46 |
99 ± 0.58* |
<5 |
99 ± 0.17* |
23 ± 1.53 |
100 |
| Capsicum frutescens |
<5 |
10 ± 0.96 |
<5 |
39 ± 3.96 |
11 ± 2.40 |
41 ± 1.08 |
| Chromolaena odorata |
13 ± 4.21 |
8 ± 3.06 |
6 ± 0.81 |
39 ± 2.12 |
Nd |
Nd |
| Crassocephalum crepidioides |
14 ± 2.14 |
51 ± 1.04* |
Nd |
10 ± 5.21 |
Nd |
9 ± 1.01 |
| Daniellia oliveri |
35 ± 1.55 |
97 ± 0.21* |
<5 |
66 ± 4.16* |
22 ± 10.50 |
47 ± 5.78 |
| Erythrophleum suaveolens |
100 |
100 |
100 |
100 |
100 |
100 |
| Hoslundia opposita |
19 ± 0.55 |
96 ± 0.42* |
Nd |
93 ± 1.67* |
Nd |
51 ± 8.21* |
| Jatropa curcas |
45 ± 4.01 |
100 |
29 ± 0.61 |
87 ± 1.52* |
Nd |
Nd |
| Landolphia dulcis |
83 ±1.39 |
100 |
Nd |
11 ± 1.21 |
Nd |
9 ± 3.11 |
| Lannea nigritana |
32 ± 0.32 |
90 ± 0.17* |
Nd |
Nd |
Nd |
21 ± 7.71* |
| Ocimum basilicum |
<5 |
<5 |
<5 |
<5 |
<5 |
Nd |
| Parkia biglobosa |
<5 |
75 ± 3.36* |
7 ± 5.13 |
72 ± 0.61 |
17 ± 7.21 |
93 ± 6.03* |
| Parkia filicoidea |
<5 |
67 ± 3.06* |
<5 27 ± 3.70 |
10 ± 0.70 |
76 ± 1.53* |
|
| Pterocarpus santalinoides |
17 ± 2.52 |
98 ± 0.45* |
<5 |
11 ± 5.03 |
<5 |
17 ± 0.40 |
| Rauvolfia vomitoria |
<5 37 ± 1.12 |
19 ± 0.72 |
33 ± 1.71 |
<5 |
8 ± 4.23 |
|
| Sida acuta |
91 ± 5.86* |
95 ± 3.16* |
25 ± 5.03 |
97 ± 0.57* |
27 ± 2.20 |
97 ± 1.80* |
| Tetrapleura tetraptera |
66 ± 1.38* |
100 58 ± 9.13* |
100 |
Nd |
Nd |
|
| Vitex doniana Bark |
<5 |
89 ± 1.27* |
Nd |
55 ± 1.33 |
Nd |
<5 |
| Root | 21 ± 1.46 | 56 ± 2.35* | Nd | 61 ± 1.06 | Nd | 57 ± 1.25 |
The antiproliferative/cytotoxic effect is expressed in terms of the percent inhibition of cells growth relative to the DMSO control after 72 h exposure to the extracts. Results are expressed as mean ± SD of three rreplicate experiments. Nd = Not determined. *There was a significant difference in cell inhibition in extract-treated cultures compared with DMSO-control in all cell lines (P<0.05).