Table 3.
IC50 (μg/mL) values for the in vitro cytotoxic activity of plants crude extracts on five human cancer cell lines
| Species | BT-549 | BT-20 | PC-3 | SW-480 | JURKAT |
|---|---|---|---|---|---|
| Allanblackia floribunda |
14.7 ± 0.23 |
48.3 ± 2.90 |
29.4 ± 0.69 |
57.1 ± 1.16 |
Nd |
| Bidens pilosa |
43.1 ± 6.09 |
53.7 ± 2.16* |
47.7 ± 2.69* |
Nd |
75.6 ± 1.06* |
| Bryophyllum pinnatum |
48.2 ± 1.56 |
82.4 ± 0.17* |
48.3 ± 1.05* |
Nd |
Nd |
| Byrsocarpus coccineus Bark |
24.6 ± 0.99 |
52.9 ± 4.11* |
43.7 ± 1.02* |
Nd |
65.2 ± 0.87* |
| Leaves |
18.6 ± 4.85 |
31.3 ± 0.53* |
29.1 ± 0.64* |
Nd |
43.4 ± 1.77* |
| Cajanus cajan |
56.1 ± 10.09 |
56.8 ± 2.60 |
50.5 ± 0.76 |
52 ± 0.53 |
Nd |
| Daniellia oliveri |
28.1 ± 0.56 |
153.1 ± 1.56 |
130.0 ± 0.45 |
147.0 ± 0.47 |
Nd |
| Erythrophleum suaveolens |
0.55 ± 0.18 |
0.50 ± 0.03 |
1.30 ± 0.14 |
0.80 ± 0.11 |
0.20 ± 0.05 |
| Hoslundia opposita |
76.4 ± 7.89 |
56.1 ± 1.57 |
59.7 ± 8.11 |
Nd |
>200 |
| Jatropa curcas |
L. 21.3 ± 0.38 |
33.4 ± 0.70 |
>200 |
>200 |
>200 |
| Landolphia dulcis |
16.3 ± 4.31 |
>200 |
>200 |
>200 |
Nd |
| Lannea nigritana |
48.2 ± 3.52 |
Nd |
>200 |
Nd |
53.5 ± 0.35* |
| Parkia biglobosa |
100.0 ± 0.67 |
125.0 ± 2.21 |
56.1 ± 0.45 |
136.0 ± 0.81 |
Nd |
| Parkia filicoidea |
149.0 ± 2.65 |
>200 |
94.3 ± 0.50 |
Nd |
Nd |
| Pterocarpus santalinoides |
57.9 ± 0.35 |
>200 |
>200 |
>200 |
10.2 ± 0.25 |
| Sida acuta |
10.3 ± 0.21 |
41.1 ± 1.05 |
37.1 ± 0.18 |
Nd |
42.3 ± 0.79 |
| Tetrapleura tetraptera |
9.1 ± 1.40 |
23.1 ± 7.05 |
Nd |
Nd |
37.5 ± 5.13* |
| Vitex doniana Bark |
62.5 ± 0.23 |
171.1 ± 1.33 |
>200 |
89.2 ± 6.65 |
84.0 ± 1.13 |
| Root | 44.9 ± 0.10 | 152.3 ± 1.22 | 177.3 ± 1.01 | 45.6 ± 1.35 | 43.4 ± 0.64 |
Results are expressed as mean ± SD (μg/mL) of three replicate experiments. Nd = Not determined. There was a significant difference in cell inhibition in extract-treated cultures compared with DMSO-control in all cell lines (P<0.05).