Table 1.
Search strategy for the identification of articles on the methods used for small clinical trials
|
Terms combined in PubMed search | |
| • |
(“Rare diseases” OR “orphan*”) AND (“Epidemiologic Methods” OR “Research Design” OR “Clinical Trials as Topic”) |
| • |
Rare disease* |
| • |
Clinical trial* |
| • |
Clinical research |
| • |
Withdrawal |
| • |
Winner* |
| • |
Loser* |
| • |
Sequential |
| • |
Adaptive |
| • |
Delayed start |
| • |
Early escape |
| • |
N-of-1 |
| • |
Randomi* |
| • |
Placebo phase |
| • |
Three stage |
|
Journals (years) hand-searched: | |
| • |
Statistics in Medicine (1990–2010) |
| • |
Orphanet Journal of Rare Diseases (2006–2010) |
| • |
Controlled Clinical Trials (2000–2004) |
| • |
Contemporary Clinical Trials (2005–2010) |
| • |
BMC Medical Research Methodology (2001–2011) |
| • |
Journal of Biopharmaceutical Statistics (1991–2012) |
| • |
Biometrical Journal (1990 – 2012) |
| • |
Statistica Sinica (1991–2012) |
| • |
Journal of Statistical Planning and Inference (1990 – 2012) |
| • |
Journal of the American Statistical Association (1990–2012) |
| • | American Journal of Biostatistics (2010 – 2012) |
* = truncation symbol used in PubMed search.