Table 2.
Sputum composition (percentage of sputum leukocytes and cell count)
| |
ANOVA |
||||
|---|---|---|---|---|---|
| Baseline | LPS 1 | LPS 2 | LPS Tx | p | |
| Macrophages (%)§ |
68.7 ± 5.3 |
19.1 ± 2.9*** |
25.9 ± 3.5*** |
27 ± 4.5*** |
<0.001 |
| Neutrophils (%)§ |
25.2 ± 5.0 |
72.3 ± 3.4*** |
61.5 ± 3.5*** |
61.8 ± 4.6*** # |
<0.001 |
| Eosinophils (%)§ |
0.0 ± 0.0 |
0.1 ± 0.0 |
0.2 ± 0.1 |
0.1 ± 0.1 |
n.s. |
| Lymphocytes (%)§ |
0.7 ± 0.2 |
0.5 ± 0.2 |
0.5 ± 0.2 |
0.4 ± 0.1 |
n.s. |
| Monocytes/sm. MФ (%)§ |
5.3 ± 0.9 |
7.9 ± 1.4 |
11.9 ± 1.5*** # |
10.7 ± 0.9** |
0.001 |
| Cummulative Response (%)§ |
30.5 ± 5.4 |
80.3 ± 3.0*** |
73.3 ± 3.5*** |
72.5 ± 4.5*** |
<0.001 |
| Sq. cells (% TCC)& |
7.7 (1.4) |
2.9 (1.2)*** |
2.5 (1.4)*** |
2.8 ± 1.3*** |
<0.001 |
| Total cell count (106/mL)& |
2.40 (1.2) |
10.46 (1.2)*** |
5.08 (1.2)** ## |
3.7 (1.2)*### |
<0.001 |
| Macrophages (106/mL)& |
1.43 (1.2) |
1.73 (1.2) |
1.11 (1.3) |
0.80 (1.2)* # |
0.02 |
| Neutrophils (106/mL)& |
0.39 (1.5) |
7.29 (1.3)*** |
2.91 (1.3)***## |
2.10 (1.2)***### |
<0.001 |
| Non-Sq. epithelia cells (106/mL)& |
0.15 (1.4) |
0.12 (1.5) |
0.14 (1.5) |
0.09 (1.4) |
n.s. |
| Monocytes/sm. MФ (106/mL)& |
0.10 (1.3) |
0.66 (1.4)*** |
0.52 (1.3)*** |
0.36 (1.2)*** |
<0.001 |
| Cummulative Response (106/mL)& | 0.53 (1.4) | 8.13 (1.2)*** | 3.47 (1.2)***## | 2.51 (1.2)***### | <0.001 |
§ mean and standard error of the mean (SEM) of percent sputum leukocytes, & geometric mean and geometric standard error (SEM as a factor), TCC: total cell count; Sq: Squamous; sm. MФ: small macrophages; ANOVA: repeated measures ANOVA, Newman-Keuls post-hoc test: * p < 0.05, ** p < 0.01, *** p < 0.001 compared with baseline; # p < 0.05, ## p < 0.01, ### p < 0.001 compared with LPS 1. Cumulative response = Sum of neutrophils, monocytes and small macrophages.