Table 1.
Clinical Characteristics of the Study Population by FTO rs1861868 Genotypesa
| AA (n = 166) | AG (n = 333) | GG (n = 203) | P Value | |
|---|---|---|---|---|
| Characteristic | ||||
| Women, % | 47.0 | 49.6 | 41.9 | .42 |
| Age, y | 43.4 ± 14.9 | 43.2 ± 14.1 | 44.6 ± 13.6 | .38 |
| BMI | 27.4 ± 4.8 | 26.5 ± 4.5 | 25.9 ± 4.1 | <.001 |
| Waist circumference, cm | 89.3 ± 11.4 | 86.9 ± 11.0 | 86.4 ± 10.5 | .003 |
| Weight, kg | 76.5 ± 12.9 | 74.3 ± 13.1 | 73.0 ± 11.8 | .002 |
| Height, cm | 167.5 ± 8.7 | 167.4 ± 9.3 | 167.6 ± 9.7 | .81 |
| Overweight (25 ≤BMI <30), % | 64.5 | 57.1 | 56.7 | .05 |
| Obese (BMI ≥30), % | 27.1 | 18.3 | 15.8 | .006 |
| Total daily accelerometer counts/1000, median (25%, 75% percentiles) | 362 (288, 538) | 392 (273, 572) | 427 (285, 610) | |
| Physical activityb | −0.05 ± 0.43 | 0.002 ± 0.45 | 0.04 ± 0.49 | .11 |
|
| ||||
| Fat and Lean Massc | ||||
| (n = 82) | (n = 169) | (n = 103) | ||
| Total fat mass, kg | 21.8 ± 9.9 | 20.5 ± 9.5 | 18.5 ± 9.2 | <.001 |
| Total lean mass, kg | 55.3 ± 9.8 | 52.6 ± 9.6 | 51.8 ± 10.8 | .02 |
| Total % fat | 27.8 ± 10.1 | 27.5 ± 10.3 | 25.8 ± 10.7 | .001 |
Abbreviation: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared).
a
Data are given as mean ± SD except where noted; “n” indicates the number of samples.
b
Group means for age- and sex-residualized daily physical activity counts.
c
Measures of body composition as determined by dual-energy x-ray absorptiometry (DEXA).