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. 2013 Apr 4;13:179. doi: 10.1186/1471-2407-13-179

Figure 9.

Figure 9

Determination of fibrotic changes in murine lungs at 16 weeks post-XRT. Mice were pre-fed 0% FLC for 72 hours prior to single fraction thoracic X-ray radiation therapy (13.5 Gy). Following XRT exposure, mouse cohorts (n=15) were fed 10% FLC or 20% FLC diets initiated 24, 48, or 72 hours post-XRT. Control-fed mouse cohorts remained on 0% FLC diet throughout the course of the study. Lungs were harvested at 16 weeks post-XRT. Panel A: Evaluation of hydroxyproline content in lungs. Data is represented as mean ± SEM. *p< 0.05 for irradiated 0% FLC vs. irradiated 10% FLC and 20% FLC, #p≤ 0.01 for irradiated 0% FLC vs. irradiated 20% FLC (+48 and +72 hours), $p≤ 0.001 for irradiated 0% FLC vs. irradiated 10% FLC (+24 hours). Panel B: Fibrotic Index (range=0-4) scoring. Data is represented as mean ± SEM. *p< 0.05 for irradiated 0% FLC vs. 10% FLC (+48 hours).