Table 2.
LINGO1 genotype and allelic variants of patients with multiple sclerosis (MS) and healthy volunteers
| MS PATIENTS (N = 293, 586 ALLELES) | CONTROLS (N = 318, 636 ALLELES) | Intergroup comparison values | MS WOMEN (N = 203, 406 ALLELES) | CONTROL WOMEN (N = 221, 442 ALLELES) | Intergroup comparison values | MS MEN (N = 90, 180 ALLELES) | CONTROL MEN (N = 97, 194 ALLELES) | Intergroup comparison values | |
|---|---|---|---|---|---|---|---|---|---|
| rs9652490 GENOTYPE A/A |
197 (67.2%) |
222 (69.8%) |
|
139 (68.5%) |
153 (69.2%) |
|
58 (64.4%) |
69 (71.1%) |
|
| A/G |
92 (31.4%) |
86 (27.0%) |
P = 0.197 |
62 (30.5%) |
60 (27.1%) |
P = 0.170 |
30 (33.3%) |
26 (26.8%) |
P = 0.651 * |
| G/G |
4 (1.4%) |
10 (3.1%) |
|
2 (1.0%) |
8 (3.6%) |
|
2 (2.2%) |
2 (2.1%) |
|
| Allele A |
486 (82.9%) |
530 (83.3%) |
-- |
340 (83.7%) |
366 (82.8%) |
-- |
146 (81.1%) |
164 (84.5%) |
-- |
| Allele G |
100 (17.1%) |
106 (16.7%) |
OR (95% CI) |
66 (16.3%) |
76 (17.2%) |
OR (95% CI) |
34 (18.9%) |
30 (15.5%) |
OR (95% CI) |
| 1.03 (0.76-1.39) |
0.94 (0.65-1.34) |
1.27 (0.74-2.18) |
|||||||
| P = 0.853 |
P = 0.715 |
P = 0.380 |
|||||||
| rs11856808 GENOTYPE C/C |
137 (46.8%) |
145 (45.6%) |
|
95 (46.8%) |
101 (45.7%) |
|
42 (46.7%) |
44 (45.4% |
|
| C/T |
126 (43.0%) |
149 (46.9%) |
P = 0.407 |
90 (44.3%) |
103 (46.6%) |
P = 0.852 |
36 (40.0%) |
46 (47.4%) |
P = 0.313 |
| T/T |
30 (10.2%) |
24 (7.5%) |
|
18 (8.9%) |
17 (7.7%) |
|
12 (13.3%) |
7 (7.2%) |
|
| Allele C |
400 (68.3%) |
439 (69.0%) |
-- |
280 (69.0%) |
305 (69.0%) |
-- |
120 (66.7%) |
134 (69.1%) |
-- |
| Allele T |
186 (31.7%) |
197 (31.0%) |
OR (95% CI) |
126 (31.0%) |
137 (31.0%) |
OR (95% CI) |
60 (33.3%) |
60 (30.9%) |
OR (95% CI) |
| |
|
|
1.04 (0.81-1.32) |
|
|
1.00 (0.75-1.34) |
|
|
1.08 (0.60-1.43) |
| P = 0.773 | P = 0.990 | P = 0.725 |
P values correspond to 3x2 contingency tables (exact test). * Fisher’s exact test.