Table 3.
LINGO1 genotypes and allelic variants in patients with MS, and relation with the evolutive type of MS
| RELAPSING-REMITTING MS (N = 159; 318 ALLELES) | Intergroup comparison values | SECONDARY PROGRESSIVE MS (N = 91; 182 ALLELES) | Intergroup comparison values | PRIMARY PROGRESSIVE MS (N = 43; 86 ALLELES) | Intergroup comparison values | CONTROLS (N = 318, 636 ALLELES) | |
|---|---|---|---|---|---|---|---|
| rs9652490 GENOTYPE | |||||||
| A/A |
102 (64.2%) |
62 (68.1%) |
|
33 (76.7%) |
|
222 (69.8%) |
|
| A/G |
56 (35.2%) |
P = 0.055 |
26 (28.6%) |
P =0.956 |
10 (23.3%) |
P = 0.405 |
86 (27.0%) |
| G/G |
1 (0.6%) |
|
3 (3.3%) |
|
0 (0.0%) |
|
10 (3.1%) |
| Allele A |
260 (81.8%) |
-- |
150 (82.4%) |
-- |
76 (88.4%) |
-- |
530 (83.3%) |
| Allele G |
58 (18.2%) |
OR (95% CI) |
32 (17.6%) |
OR (95% CI) |
10 (11.6%) |
OR (95% CI) |
106 (16.7%) |
| 1.12 (0.78-1.59) |
1.07 (0.69-1.65) |
0.66 (0.33-1.31) |
|||||
| P = 0.544 |
P = 0.771 |
P = 0.232 |
|||||
| rs11856808 GENOTYPE | |||||||
| C/C |
67 (42.1%) |
|
43 (47.3%) |
|
27 (62.8%) |
|
145 (45.6%) |
| C/T |
77 (48.4%) |
P = 0.670 |
35 (38.5%) |
P = 0.095 |
14 (32.6%) |
P = 0.112 |
149 (46.9%) |
| T/T |
15 (9.4%) |
|
13 (14.3%) |
|
2 (4.7%) |
|
24 (7.5%) |
| Allele C |
211 (66.4%) |
-- |
121 (66.5%) |
-- |
68 (79.1%) |
-- |
439 (69.0%) |
| Allele T |
107 (33.6%) |
OR (95% CI) |
61 (33.5%) |
OR (95% CI) |
18 (20.9%) |
OR (95% CI) |
197 (31.0%) |
| |
|
1.13 (0.85-1.51) |
|
1.12 (0.79-1.60) |
|
0.59 (0.34-1.02) |
|
| P = 0.404 | P = 0.515 | P = 0.056 | |||||
P values correspond to 3x2 contingency tables (exact test).