Table 3.
Multivariable Cox PH analyses for OS and RFS
| |
Overall survival |
Recurrence free survival |
||||
|---|---|---|---|---|---|---|
| Variables | HR | 95% CI | p value | HR | 95% CI | p value |
| Age at surgery 1, a |
1.27 |
0.84–1.91 |
0.255 |
1.00 |
0.67–1.48 |
0.982 |
| Lymph node ratio |
|
|
0.007 b,* |
1.02 |
|
0.020 b,* |
| Within High 53BP1 level strata 2, a |
0.98 |
0.43–2.22 |
0.958 |
3.92 |
0.45–2.29 |
0.963 |
| Within Low 53BP1 level strata 2, a |
4.84 |
2.26–10.37 |
<0.001* |
|
1.79–8.58 |
<0.001* |
| CA19-9 |
|
|
0.040 b,* |
|
|
0.226 b |
| Within High 53BP1 level strata 3, a |
0.87 |
0.52–1.47 |
0.606 |
0.94 |
0.56–1.57 |
0.803 |
| Within Low 53BP1 level strata 3, a |
1.72 |
1.18–2.51 |
0.005* |
1.38 |
0.97–1.96 |
0.077 |
| Adjuvant chemotherapy: Yes |
0.34 |
0.19–0.60 |
<0.001* |
0.55 |
0.30–1.00 |
0.051 |
| Margin Positive |
2.37 |
1.35–4.14 |
0.003* |
1.36 |
0.75–2.47 |
0.316 |
| Peripancreatic extension status Positive |
2.29 |
1.12–4.65 |
0.022* |
2.41 |
1.16–5.01 |
0.019* |
| Perineural invasion status Positive | 0.52 | 0.29–0.95 | 0.033* | 0.46 | 0.25–0.81 | 0.008* |
a: upper quartile vs. lower quartile.
b: P value for interaction terms with 53BP1 Level.
1: 73.10 vs. 58.38.
2: 25.69% vs. 0%.
3: 519.75 vs. 50.
*: statistically significant.