Table 1.
List of potentially novel and novel lipid associated complexes implicated in liver cancer
| Novelty | CORUM ID | Complex name | Function | Lipid involvement |
|---|---|---|---|---|
| PN |
1096 |
SNX and PDGF receptor complex |
reported to be involved in transport and transmembrane signal transduction |
lipid involvement yes |
| PN |
1104 |
Transferrin receptor complex |
reported involved in transport and receptor mediated endocytosis |
lipid association yes |
| PN |
563 |
Complex V; F1F0 ATPase |
energy production, mitochondrial processes, particularly in heart muscle |
lipid involvement yes |
| PN |
654 |
BLOC1-BLOC2 complex |
transport and targeting |
lipid involvement potentially novel |
| PN |
142 |
CD147-gamma-secretase complex (APH-1a, PS-1, PEN-2, NCT variant) |
signaling, protein fate |
lipid involvement yes |
| PN |
652 |
AP3-Bloc1-complex |
transport |
lipid involvement yes |
| PN |
657 |
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
protein targeting and transport |
lipid involvement yes |
| PN |
2837 |
Profilin 1 complex |
cytoskeleton organisation, endocytosis, potential metastasis involvement |
lipid involvement yes |
| PN |
1060 |
Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
transport |
lipid association yes |
| N |
280 |
HMGB1-HMGB2-HSC70-ERP60-GAPDH complex |
DNA repair, nucleic acid binding, response to stress and DNA damage stimulus);high cancer association |
lipid involvement not immediately decipherable |
| N |
312 |
Cell cycle kinase complex CDK4l |
cell cycle control, cancer association yes |
lipid involvement not immediately decipherable |
| N |
247 |
RalBP1-CCNB1-AP2A-NUMB-EPN1 complex |
cell cycle control, endocytosis |
lipid involvement not immediately decipherable |
| N |
5230 |
CHUK-NFKB2-REL-IKBKG-SPAG9-NFKB1-NFKBIE-COPB2-TNIP1-NFKBIA-RELA-TNIP2 complex |
Signaling, cancer association yes |
lipid involvement not immediately decipherable |
| N |
311 |
Cell cycle kinase complex CDK2 |
cell cycle control, cancer association yes |
lipid involvement not immediately decipherable |
| N |
5423 |
HSP70-BAG5-PARK2 complex |
protein folding and stabilisation |
lipid involvement not immediately decipherable |
| N | 2390 | CD98-LAT2-ITGB1 complex | cell adhesion, may define cell polarity which in turn has to do with invasiveness | lipid involvement not immediately decipherable |
*PN – potentially novel, N – novel.