Figure 4. BMP15 multi-species sequences alignment and position of sheep mutations.

The BMP15 protein sequences from Ovis aries (GenBank AAF81688.1), Bos taurus (GenBank DAA12832.1), Sus scrofa (GenBank NP_001005155.1), Mus musculus (GenBank NP_033887.1) and Homo sapiens (GeneBank NP_005439.2) were aligned and compared. Grey boxes and arrows represent known mutations as reviewed in Otsuka et al. [12]. FecX^Gr and FecX^O mutations are in red or green frames, respectively, themselves into bigger frames symbolizing conserved protein motifs.