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. 2013 Mar 15;14:33. doi: 10.1186/1471-2202-14-33

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Copyright © 2013 Chio et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Etanercept decreased FPI-induced increases in the number of co-localization of microglia and TNF-α specific marker cells in ischemic hippocampal regions. The FPI+saline group (▤) showed a significant increase of the numbers of co-localization of microglia and TNF-α specific marker cells cells in the ischemic hippocampus 72 h after FPI compared with the Sham controls (■) (*P < 0.01). Representative panel staining 72 h after FPI, respectively, for (A) a sham operation rat, (B) a FPI+saline rat and (C) a FPI+etanercept rat. (D) The FPI+etanercept group (▩) showed a significant decrease in the number of co-localization of microglia and TNF-α specific marker cells in ischemic hippocampus compared with the FPI+saline group (▤) (⁺P < 0.01). Each column and bar is the mean ± SD of eight rats per group.