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. 2013 Apr 25;7(4):e2171. doi: 10.1371/journal.pntd.0002171

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Ingenuity Pathway Analysis software was used to analyze a list of 360 genes which were found to be strongly upregulated following LASV challenge. Of this list, 65 were found to be directly or indirectly connected according to Ingenuity's database of published interactions. Nodes represent individual gene products, with official gene symbols included. Edges without arrows indicate a direct interaction between two gene products, e.g. a protein-protein interaction. Edges with arrows represent a regulation of transcription, directed from the gene regulator to a regulated gene. Loops indicate self-regulation. Notable in the expression profiles is the upregulation of STAT1 and IRF7, MMP9 and ELANE signaling nodes.