Table 2.
Cumulative incidence of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) and risk for CIN2+ among normal women or women with CIN1 at baseline, stratified by HPV viral load at baseline.
| Group | Baseline HPV Viral Load | No. CIN2+/No. women | Cumulative Incidence of CIN2+ | aHR† | 95% CI |
|---|---|---|---|---|---|
| Normal n=1461 |
Negative | 2/1302 | 0.2% | 1 | - |
| Low | 1/68 | 1.5% | 11.0 | 1.0–123.1 | |
| Moderate | 5/49 | 10.2% | 66.3 | 12.6–347.3 | |
| High | 3/42 | 7.1% | 49.0 | 8.2–294.0 | |
| CIN1 n=99 |
Negative | 0/42 | - | - | - |
| Low | 0/8 | - | - | - | |
| Moderate | 2/14 | 14.3% | - | - | |
| High | 6/35 | 17.1% | - | - | |
| CIN1 or Normal n=1560 |
Negative | 2/1344 | 0.1% | 1 | - |
| Low | 1/76 | 1.3% | 10.0 | 0.9–110.7 | |
| Moderate | 7/63 | 11.1% | 75.1 | 15.5–364.2 | |
| High | 9/77 | 11.7% | 83.5 | 18.0–387.5 |
†
aHR=Hazard Ratio adjusted for age, number of full-term births and number of lifetime sexual partners.