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The impact of nAChR stimulation on reaction time (RT) in smokers and nonsmokers. (A) Across all smokers, nicotine-induced effects observed under placebo pill sessions were absent under active medication as varenicline decreased RT (grey line) and attenuated nicotine’s impact thereon (red line). (B) Although nonsmokers displayed a physiological (HR) response to drugs, pharmacological manipulations did not significantly impact their behavioral performance. * pcorrected < 0.05.
