Table 2. Statistics of molecular descriptors of natural products in UNPD and FDA-approved drugs in DrugBank.

Descriptors		Natural products in UNPD				Approved drugs
	Mean	Median	Min	Max	Mean	Median	Min	Max
AlogP	2.788±3.352	2.710	−36.007	53.473	1.899±2.814	2.164	−12.834	14.242
Molecular_Weight	472.6±265.7	406.5	16.0	3973.5	360.8±199.1	322.1445	6.9	1639.9
Num_Rotatable_Bonds	6.6±6.8	5	0	140	5.5±4.9	4	0	44
Num_Rings	3.7±2.4	3	0	32	2.7±1.6	3	0	10
Num_Aromatic_Rings	0.9±1.3	0	0	20	1.3±1.1	1	0	8
Num_H_Acceptors	7.5±6.7	6	0	104	5.2±4.2	4	0	51
Num_H_Donors	3.4±4.1	2	0	64	2.3±2.6	2	0	23
Molecular_Volume	323.8±172.5	278.5	19.2	2576.2	238.0±128.1	217.8	6.8	1053.3
Molecular_Surface_Area	462.4±249.4	400.2	33	4020.9	347.7±186.4	312.45	16.6	1586.9
Molecular_Polar_Surface_Area	122.2±110.6	87.0	0	1917.9	93.9±84.1	75.0	0	878.8
Molecular_Fractional_PolarSurfaceArea	0.248±0.128	0.233	0	1	0.277±0.171	0.242	0	1
Molecular_SASA	683.0±295.7	612.5	0	5106.7	563.7±232.6	523.3	137.9	2167.1
Molecular_PolarSASA	194.9±169.3	142.1	0	3101.9	152.1±131.0	126.0	0	1321.8
Molecular_FractionalPolarSASA	0.268±0.144	0.242	0	0.967	0.272±0.171	0.239	0	0.933
Molecular_SAVol	591.7±253.7	531.5	0	4468.8	495.9±202.2	462.8	124.3	1900.9

Note: the descriptors of 197201 natural products in UNPD and 1380 FDA-approved small molecule drugs in DrugBank were calculated by Discovery Studio.