Figure 7. SNF5 is a key executor of epigenetic regulation in pluripotency and differentiation.

(A and B) Differentiation signals cause recruitment of SNF5 to both OCT4 activated and repressed target genes with distinctive roles (closing or generating NDRs) dependent on cellular context. Changes in exogenous SNF5 levels disrupt the balance between pluripotent and differentiated states. (Refer to Discussion for a detailed explanation).