Table 2. Association of FNDC5 SNPs rs16835198, rs3480, rs726344, and rs1746661 with glycaemia and insulin sensitivity (statistics).

SNP	Genotype	N Overallstudy group	HWE	Fasting glucose(mmol/L)	Glucose 120 minOGTT (mmol/L)	Fasting insulin(pmol/L)	HOMA-IR(*10–6 mol*U*L–2)	ISI OGTT(*1015 L2*mol–2)	N Clampsubgroup	ISI Clamp(*106 L*kg–1*min–1)
rs16835198	GG/GT/TT	844/892/238	p = 0.9	β = –0.0003 p = 0.9	β = 0.0005 p = 1.0	β = –0.0457 p = 0.0118 #	β = –0.0459 p = 0.0179	β = 0.0480 p = 0.0126 #	209/221/55	β = 0.0081 p = 0.8
rs3480	AA/AG/GG	689/928/355	p = 0.2	β = 0.0012 p = 0.7	β = 0.0007 p = 0.9	β = 0.0281 p = 0.1	β = 0.0294 p = 0.1	β = –0.0286 p = 0.1	159/240/86	β = 0.0022 p = 0.9
rs726344	GG/GA/AA	1,590/359/22	p = 0.7	β = 0.0111 p = 0.0281	β = 0.0071 p = 0.6	β = 0.0708 p = 0.0131	β = 0.0817 p = 0.0073 #	β = –0.0809 p = 0.0074 #	381/94/9	β = 0.0778 p = 0.1
rs1746661	GG/GT/TT	1,240/627/105	p = 0.0292	β = –0.0010 p = 0.8	β = 0.0050 p = 0.6	β = 0.0243 p = 0.2	β = 0.0237 p = 0.3	β = –0.0094 p = 0.7	304/151/30	β = –0.0361 p = 0.3

Prior to statistical analysis, all parameters were adjusted for gender, age, and bioelectrical impedance-derived percentage of body fat. Nominal associations are marked by bold fonts;

^#significant after Bonferroni correction (p<0.0127). HOMA-IR – homeostasis model assessment of insulin resistance; HWE – Hardy-Weinberg equilibrium; ISI – insulin sensitivity index; OGTT – oral glucose tolerance test; SNP – single nucleotide polymorphism.