Table 1. Genotypic frequencies of polymorphisms within the HERV-K18 sequence in autoimmune disease Spanish patients and controls.
| SNP1 | SNP2 | ||||||||
| AA | AG | GG | GG | AG | AA | ||||
| n (%) | n (%) | n (%) | n (%) | n (%) | n (%) | ||||
| Controls | 225 (37) | 286 (48) | 90 (15) | 188 (31) | 298 (50) | 112 (19) | |||
| MS | Overall | 372 (39) | 417 (44) | 153 (16) | 334 (36) | 422 (45) | 175 (19) | ||
| 1501 | 1501+ | 114 (37) | 128 (42) | 64 (21)1 | 128 (42)2 | 121 (40) | 53 (18) | ||
| 1501− | 196 (39) | 241 (48) | 70 (14) | 155 (31) | 246 (49) | 102 (20) | |||
| RA | Overall | 197 (43) | 192 (42) | 65 (14) | 132 (30) | 231 (52) | 79 (18) | ||
| SE | SE+ | 107 (44) | 105 (43) | 31 (13) | 65 (28) | 133 (56) | 38 (16) | ||
| SE− | 64 (40) | 69 (43) | 27 (17) | 51 (32) | 77 (49) | 29 (18) | |||
1
GG vs AG+AA: MS 1501+ vs 1501−: p = 0.01; MS 1501+ vs. Controls: p = 0.02, OR (95%CI) = 1.50 (1.04–2.17).
2
GG vs AG+AA: MS 1501+ vs 1501−: p = 0.0009; MS 1501+ vs. Controls: p = 0.001, OR (95%CI) = 1.60 (1.19–2.16).