Fig. 3.

Intracellular AβpE3 aggregates are present in astrocytes in human brain. Epifluorescent microscopic images of double fluorescent immunohistochemistry stainings for AβpE3 oligomers and GFAP or CR3/43. Paraffin-embedded sections from temporal cortex of an AD patient were double stained with GFAP (red) as marker for astrocytes (a, b) or with CR3/43 (red) as a marker for microglia (c), and with the O-AβpE3 antibody (green). The arrow shows the typical star-like O-AβpE3 staining pattern associated with glial cell staining while CR3/43 staining is clearly absent. Scale bar, 25 μm