Fig. 2.

Reversal of epigenetic regulation of histone H3 acetylation by the histone deacetylase inhibitor trichostatin A (TSA). H3 acetylation was increased for all ages up to 11 months in 3xTg-AD neurons and for ages beyond 2 months in non-transgenic neurons. Indicated neurons were treated with TSA (solid boxes) or vehicle alone (DMSO; open boxes). For non-transgenic, n = 43–223 neurons; 3xTg-AD, n = 45–261 neurons from 2–7 animals for each treatment