Table 6.
Multivariate proportional mortality hazard ratios (HRs) by fat–lean mass ratio (FLMR) and fitness category in study participants
| Fitness categorya | No. of subjects | No. (%) of deaths | P trendsb | HR (95% CI)c | P value |
|---|---|---|---|---|---|
| FLMR 1st quartile | |||||
| Low fitness | 265 | 74 (27.9) | 0.000 | 2.16 (1.07–4.39) | 0.033 |
| Moderate fitness | 288 | 69 (24.0) | 2.31 (1.13–4.70) | 0.022 | |
| High fitness | 447 | 53 (11.9) | 1.15 (0.56–2.36) | 0.715 | |
| FLMR 2nd quartile | |||||
| Low fitness | 264 | 54 (20.5) | 0.000 | 1.59 (0.78–3.24) | 0.205 |
| Moderate fitness | 357 | 48 (13.4) | 1.30 (0.63–2.67) | 0.480 | |
| High fitness | 379 | 37 (9.8) | 1.00 (0.48–2.09) | 0.993 | |
| FLMR 3rd quartile | |||||
| Low fitness | 370 | 46 (12.4) | 0.007 | 1.44 (0.72–2.89) | 0.303 |
| Moderate fitness | 340 | 26 (7.6) | 1.02 (0.49–2.13) | 0.964 | |
| High fitness | 290 | 19 (6.6) | 0.97 (0.45–2.11) | 0.934 | |
| FLMR 4th quartile | |||||
| Low fitness | 439 | 35 (8.0) | 0.063 | 1.24 (0.61–2.51) | 0.555 |
| Moderate fitness | 354 | 16 (4.5) | 0.89 (0.40–1.96) | 0.764 | |
| High fitness | 207 | 10 (4.8) | 1 (reference) | – | |
FLMR quartiles: 1st, < 0.34; 2nd, 0.34– < 0.43; 3rd, 0.43– < 0.56; 4th, ≥ 0.56
CI confidence interval, FLMR fat–lean mass ratio
aFitness was assessed with a 6-m walk test. Fitness tertiles: 1st, walking speed < 0.88 m/s (low fitness); 2nd, walking speed 0.88– < 1.05 m/s (moderate fitness); 3 rd, walking speed ≥ 1.05 m/s (high fitness)
b P values for trend were obtained by using chi-square test (linear-by-linear association)
cAdjusted for age, sex, medical history (diabetes, stroke, hypertension, myocardial infarction, angina, and congestive heart failure), current smoking, and CVD medications (ACE inhibitor, aspirin, beta blocker, calcium channel blocker, and statin)