Table 3.
Hypothesis-driven search for significant between-group differences in CMRgl distribution across the three FCHDRP (10-year) groups and linear correlations between CMRgl values and FCHDRP (10-year) scores in the sample of elderly subjects (n = 57, including gender and mean time interval between MRI and PET data acquisitions as covariates of no interest), controlling to APOE ε4 status
| Region name (SVC)a | Hemisphere | Brodmann areas | K b | p cFWE-corrected | F/T d | Z e | p funcorrected | Coordinates x, y, z g |
|---|---|---|---|---|---|---|---|---|
| Significant CMRgl difference in comparisons across the three groups: low-risk, medium-risk, and high-risk | ||||||||
| Parahippocampal gyrus | Right | 35/36 | 34 | 0.032 | 9.00 | 3.32 | <0.001 | 32, −26, −17 |
| Significant CMRgl reduction in low-risk group in comparison to high-risk group | ||||||||
| Parahippocampal gyrus | Right | 35/36 | 133 | 0.001 | 5.08 | 4.32 | <0.001 | 32, −26, −17 |
| Left | 35/36 | 66 | 0.045 | 3.38 | 3.10 | 0.001 | −26, −30, −15 | |
| Significant CMRgl reductions in high-risk group in comparison to low-risk group | ||||||||
| Precuneus | Left | 7/23/31 | 401 | 0.008 | 4.60 | 4.00 | <0.001 | −6, −43, 37 |
| Posterior cingulate gyrus | Left | 23/31 | 71 | 0.007 | 3.89 | 3.50 | <0.001 | −4, −47, 32 |
| Significant positive correlation between CMRgl values and FCHDRP (10-year risk) scores | ||||||||
| Parahippocampal gyrus | Right | 35/36 | 114 | 0.007 | 4.00 | 3.72 | <0.001 | 30, −30, −14 |
| Left | 35/36 | 95 | 0.025 | 3.47 | 3.27 | 0.001 | −26, −32, −14 | |
CMRgl cerebral metabolic rate for glucose metabolism, FCHDRP (10-year risk) Framingham 10-year risk Coronary Heart Disease Risk Profile, MRI magnetic resonance imaging, FDG-PET positron emission tomography with 18-fluoro-2-deoxyglucose
aEach region was circumscribed using the small volume correction (SVC) approach, with anatomically defined volume-of-interests masks
bNumber of contiguous voxels that surpassed the initial threshold of p < 0.01 (uncorrected) in the statistical parametric maps
cStatistical significance after correction for multiple comparisons; inferences made at the level of individual voxels [family-wise error correction (FEW; Friston et al. 1996)]
d F or T-score value of statistical significance level in the cluster
e Z-score value of statistical significance level in the cluster
fStatistical significance level uncorrected for multiple comparisons
gTalairach and Tournoux (1988) coordinates of the maximal statistical significance within each cluster