Table 2.

Selected differentially up- or downregulated genes in both regenerated (RO) liver and hepatomas (DO) from old liver whose expression levels were also reset to those seen in normal young (NY) liver (Fig. 1a, region I)

Gene	Gene name	NY/NOa	DO/NOb	RO/NOb
Dixdc1	DIX domain containing 1	−2.9	−2.7	−3.4
Ankk1	Ankyrin repeat and kinase domain containing 1	−3.0	−2.3	−3.2
Esm1	Endothelial cell-specific molecule 1	−5.2	−3.4	−3.2
Gpc2	Glypican 2	−3.7	−3.6	−3.1
Rhobtb2	Rho-related BTB domain containing 2	−2.1	−2.8	−2.8
Rpl28	Ribosomal protein L28	−2.9	−3.3	−2.7
Dlx1	Distal-less homeobox 1	−2.7	−2.4	−2.6
Mbtps2	Membrane-bound transcription factor peptidase, site 2	−2.5	−2.2	−2.6
LACS	L-NAME induced actin cytoskeletal protein	−3.0	−2.6	−2.5
RGD1565996	Similar to DnaJ homolog subfamily B member 6 (Heat shock protein J2)	−2.8	−3.0	−2.5
Tgm3	Transglutaminase 3, E polypeptide	−3.1	−3.5	−2.5
Olr1393	Olfactory receptor 1393	−2.1	−2.2	−2.4
Scn5a	Sodium channel, voltage-gated, type V, alpha polypeptide	−3.3	−2.3	−2.1
Eml4	Echinoderm microtubule associated protein like 4	3.6	2.7	2.2
Nrp1	Neuropilin 1	2.4	2.5	2.4
RGD1562100	Similar to ADP-ribosylation factor interacting protein 2 (arfaptin 2)	3.0	3.1	3.1
Caskin1	CASK-interacting protein 1	3.6	3.4	3.4
Cap350	Centrosome-associated protein 350	8.1	3.5	3.4

^aFold change (FC) was calculated between the mean values of NO (normal old) and NY (normal young)

^bFold change (FC) was calculated between the mean values of NO (normal old) and DO (hepatoma) as well as RO (regenerated)