Table 2. Quantitation of chromosomal abnormalities in metaphase spreads from three independently derived cancer cell lines from Sprr2f-Cre; Pot1aL/L; p53L/L mice.
# Metaphase anomalies | % Normal metaphase | % Aberration metaphases | % Cells w/breaks | % Cells w/fusions | Fusion/metaphase | % Poly/tetraploid | c-anaphase | |
---|---|---|---|---|---|---|---|---|
#1 | 45 | 15.5 | 20 | 4.4 | 13.3 | 0.18 | 66.7 | 15.5 |
#2 | 36 | 13.9 | 22.2 | 5.5 | 19.4 | 0.25 | 77.8 | 2.8 |
#3 | 32 | 0 | 100 | 12.5 | 100 | 3.9 | 84.4 | 0 |
The data reveal that most cells harbor significant abnormalities.