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. 2013 Apr 26;4:62. doi: 10.3389/fgene.2013.00062

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Copyright © 2013 Ross, Arighi, Ren, Natale, Huang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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Evolutionary relationship of BUB1, BUB1B, and MAD3. (A) PRO search results page showing the terms retrieved in a search for “PFAM:PF08311.” Fields shown in the display were set using “Display Options.” (B) Combined Cytoscape web view of the BUB1/BUB1B family term (PR:000035665) and the MAD3 gene-level term (PR:000035499) (blue nodes). Advanced display options were set to include family, gene, and gene-organism terms only. The BUB1 and BUB1B gene-level nodes are orange. Diagrams of the MAD3 and BUB1/BUB1B proteins show the location of Pfam domains PF08311 (MAD3/Bub1 homology domain I) and PF00069 (protein kinase domain).