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. 2013 Apr 15;447(1-2):124–131. doi: 10.1016/j.ijpharm.2013.02.034

Table 3.

The linearity (R2), primary pressure for 50% de-agglomeration (DA50), maximum degree of de-agglomeration (DAmax) and critical primary pressure (CPP) of the powders deduced from dry dispersion laser diffraction.

Powder R2 DA50 (Bar) DAmax CPP (Bar)
BDP 0.9990 0.44 1.11 2.5
Bud 0.9995 0.32 1.08 2.0
FP 0.9049 1.15 1.13 3.0a
LH300 0.9997 0.23 1.06 2.0
SB 0.9979 0.25 1.06 1.0
SXb 0.9711 1.45 1.35 3.5
Tof 0.9964 0.28 1.07 3.0
a

Measured size unchanged for 2 consecutive dispersing pressures only, 3.0 and 3.5 Bar.

b

Particle size data for the lowest PP (i.e. 0.3 Bar) omitted due to poor linearity with these data included (R2 = 0.4532).