Table 2.
Intercepts and Slopes of Linear Random Effects Time Trends (Pattern Mixture Modelling) for Secondary Outcomes in Patients Classified by Day of Ceasing ICP Monitoring: Day 1–7 (Top) and Day 8–14 (Bottom)
| |
ICP monitoring ceased day 1–7 |
|||||
|---|---|---|---|---|---|---|
| |
Intercept |
Slope |
||||
| Albumin | Saline | p | Albumin | Saline | p | |
| APTT | 32.1 (0.9) | 33.3 (0.9) | 0.34 | 0.09 (0.2) | −0.17 (0.2) | 0.43 |
| INR | 1.26 (0.0) | 1.26 (0.0) | 0.99 | −0.02 (0.0) | −0.04 (0.0) | 0.07 |
| Platelets | 159.8 (14.4) | 183.0 (15.6) | 0.27 | 9.48 (4.5) | 5.44 (4.5) | 0.52 |
| CSF drainagea | 38.1 (25.2) | 39.8 (26.9) | 0.96 | −2.68 (1.95) | −6.46 (2.06) | 0.33 |
| TDD morphine | 3.56 (0.27) | 4.13 (0.3) | 0.16 | −0.42 (0.07) | −0.66 (0.07) | 0.02 |
| TDD norepinephrine | 3.97 (0.3) | 4.75 (0.3) | 0.07 | −0.5 (0.07) | −0.74 (0.07) | 0.02 |
| TDD propofol | 4.28 (0.5) | 4.81 (0.5) | 0.45 | −0.45 (0.11) | −0.76 (0.11) | 0.05 |
| TDD midazolam | 2.53 (0.3) | 2.75 (0.3) | 0.65 | −0.3 (0.07) | −0.41 (0.07) | 0.26 |
| Temperature | 37.1 (0.1) | 36.7 (0.1) | 0.10 | 0.03 (0.03) | 0.16 (0.03) | 0.001 |
| Sodiuma | 144.8 (1.1) | 142.1 (1.1) | 0.08 | −0.13 (0.08) | −0.26 (0.08) | 0.34 |
| PaCO2a | 35.0 (0.9) | 35.1 (0.9) | 0.94 | −0.26 (0.08) | −0.16 (0.08) | 0.31 |
| |
ICP monitoring ceased day 8–14 |
|||||
|---|---|---|---|---|---|---|
| |
Intercept |
Slope |
||||
| Albumin | Saline | p | Albumin | Saline | p | |
| APTT | 35.3 (0.5) | 32.6 (0.5) | 0.20 | −0.33 (0.07) | −0.1 (0.07) | 0.42 |
| INR | 1.26 (0.02) | 1.2 (0.02) | 0.20 | 0.01 (0.0) | 0.01 (0.0) | 0.07 |
| Platelets | 50.3 (8.4) | 69.1 (8.1) | 0.11 | 34.3 (1.8) | 35.3 (1.8) | 0.67 |
| CSF drainagea | 56.9 (22.4) | 60.9 (19.5) | 0.89 | −2.35 (0.29) | −2.96 (0.29) | 0.82 |
| TDD morphine | 4.95 (0.17) | 5.26 (0.17) | 0.19 | −0.30 (0.02) | −0.37 (0.02) | 0.33 |
| TDD norepinephrine | 4.5 (0.19) | 4.76 (0.32) | 0.33 | 0.32 (0.02) | −0.37 (0.02) | 0.09 |
| TDD propofol | 3.64 (0.29) | 3.61 (0.28) | 0.93 | −0.12 (0.03) | −0.07 (0.03) | 0.20 |
| TDD midazolam | 4.12 (0.21) | 4.52 (0.20) | 0.17 | −0.28 (0.02) | −0.33 (0.02) | 0.08 |
| Temperature | 36.9 (0.09) | 36.8 (0.09) | 0.49 | 0.07 (0.01) | 0.08 (0.01) | 0.45 |
| Sodiuma | 145.3 (0.61) | 145.3 (0.59) | 0.99 | 0.01 (0.01) | 0.01 (0.01) | 0.72 |
| PaCO2a | 36.6 (0.46) | 35.9 (0.43) | 0.31 | −0.03 (0.01) | −0.00 (0.01) | 0.29 |
Data are shown as mean (standard deviation).
a
Quadratic term was included in the model for these variables.
Units for intercepts: activated partial thromboplastin time (APTT): seconds; international normalized ratio (INR); platelet count: ×109/L; cerebrospinal fluid (CSF) drainage: mL/day; total daily dose (TDD) of drugs transformed by log, temperature: oC; sodium: mmol/L; arterial carbon dioxide tension (PaCO2): mmHg.
Slopes are expressed as positive for increase, negative for decrease.
ICP, intracranial pressure.