FIG. 2.

Mean (±SEM) walking ability as measured by time (sec) to traverse an elevated wooden beam prior to, and after, traumatic brain injury (TBI) or sham injury. All TBI+donepezil groups were significantly impaired relatively to the SHAM group (**p<0.0001). At the two highest doses of chronic donepezil (TBI+donepezil: 2.0 and 3.0 mg/kg), rats displayed significantly slower recovery in beam walk ability during the 5 testing days compared with TBI+vehicle, TBI+donepezil (0.5 m/kg), and TBI+donepezil (1.0 mg/kg) (*p<0.0005, Bonferroni post-hoc tests).