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Mean (±SEM) time (sec) to locate a hidden (submerged) platform in the Morris water maze test. There were substantial traumatic brain injury (TBI)-induced water maze performance deficits in all TBI groups compared with SHAM controls (**p<0.0001). At the highest donepezil dose (3.0 mg/kg), TBI rats displayed significantly slower recovery rates of spatial learning abilities compared with the TBI+vehicle group (*p<0.0001) and the TBI+donepezil (0.5 mg/kg) group (p<0.0021).
