FIG. 1.

LKB1 MKO mice are exercise intolerant and display reduced oxygen uptake and limited FA oxidation during exercise in vivo. A: Maximal-speed running test of LKB1 MKO and WT mice was performed. B and C: RER (B) and oxygen uptake (C) (mL ⋅ h⁻¹ ⋅ kg⁻¹) during treadmill exercise at 60% of maximal running speed and at the same absolute intensity. Whole-body FA oxidation (kJ ⋅ h⁻¹ ⋅ kg⁻¹) (D) and carbohydrate (CHO) oxidation (kJ ⋅ h⁻¹ ⋅ kg⁻¹) (E) were calculated from RER values as described in research design and methods. Data are presented as means ± SEM (n = 11–12). **P < 0.01, ***P < 0.001, significantly different from WT; #P < 0.05, significant difference between WT groups.