FIG. 2.

HFD potentiates spatial learning impairments in THY-Tau22 mice. TC animals exhibited significantly increased escape latency (A) and path length (B) as compared with WC animals. Although HFD did not exert significant influence on both parameters in WT animals, escape latency and path length were further increased in TH mice as compared with TC animals. Results are expressed as means ± SEM. WC vs. TC: *P < 0.05, **P < 0.01; TC vs. TH: #P < 0.05 using 2W-ANOVA. Open circles, WC; black squares, TC; crossed circles, WH; open squares, TH.