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. 2013 Apr 16;62(5):1519–1526. doi: 10.2337/db12-1066

FIG. 3.

FIG. 3.

ATP-dependent glucose uptake requires the PI3K-Akt axis. A and B: 2-NBDG uptake was measured in primary myotubes preincubated for 30 min with or without LY294002 (40 μmol/L) or Akt 1/2 inhibitor (10 μmol/L). C: Myotubes were transiently transduced with AdAkt-dn, AdAkt-myr, or Ad-empty, and 2-NBDG uptake was assayed. Values represent the mean ± SD. **P < 0.001, *P < 0.01 vs. basal group; ††P < 0.001 relative to ATP-treated cells; ##P < 0.001 relative to the control group; and ***P < 0.05 relative to nonstimulated. Data are from at least four independent experiments.