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. 2013 Apr 16;62(5):1569–1580. doi: 10.2337/db12-0849

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© 2013 by the American Diabetes Association.

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FIG. 4. — T₃ treatment results in differential changes of thyroid receptor proteins and islet gene expression. Islets from T₃-treated and untreated animals at postnatal day (P) 7 immunostained for THRA (A) and THRB (C) or from MMI-treated rats at P21 stained for THRA (B) and THRB (D). Representative confocal images were taken at the same settings for each protein so differences in intensity reflect differences in protein. At least three animals each group. Changes in Dio1, Dio2, and Dio3 (n = 3) (E) and key islet gene (n = 18) (F) mRNA in islets isolated from T₃-treated and untreated control pups by quantitative PCR at P7. Values shown as mean ± SEM; *P < 0.05 with respect to control animals at P7.