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. 2013 Apr 16;62(5):1623–1633. doi: 10.2337/db12-0981

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© 2013 by the American Diabetes Association.

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FIG. 4. — α-Cell UCP2 deletion reduces the gluconeogenic response of the liver and switches fatty acid usage during a prolonged fast. Blood glucose (A), plasma glucagon (B), and plasma insulin (C) measured in fed, 24-h fasted (fasting), and 12-h re-fed mice. *P < 0.05. D–H: Hepatic expression of the enzymes Pepck (D), G6pc (E), Fbp1 (F), Gck (G), and Fasn (H) genes. N = 4–8/group. *P < 0.05 or **P < 0.01 compared with Gcg-cre. I: Hepatic glycogen levels. N = 4–6 mice/condition. *P < 0.05. J: Metabolomic analyses of MCFA and long-chain fatty acid (LCFA) plasma levels. Data are relative to Gcg-cre levels. N = 8 mice/genotype. *P < 0.05 genotype/fed-state interaction.