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Synthesis of lipid A mimetics D1 and D7: a) succinic anhydride, dry py, RT, 97%; b) compound 2, HOBt, DIC, DIPEA, DMF, 0°C→RT, 70%; c) 1:1 TFA in CH2Cl2, RT, 86%; d) SO3.py, CH2Cl2 dry, 50% e) (iPr)2NP(OBn)2, imidazolium trifluorocaetate, then oxidation with m-chloroperbenzoic acid, 43%; f) H2/Pd-C in MeOH-THF-AcOH (71%).
