Table 1.
Clinical characteristics of the study population in the initial discovery sample used for genome-wide association study (n=783) and in the replication cohort (n=307)
|
N (%) or median (range) |
||
|---|---|---|
| Variables | Discovery sample | Replication sample |
| Sex | ||
| Male | 329 (42.0) | 136 (44.3) |
| Female | 454 (58.0) | 171 (55.7) |
| Age of onset (years) | 57.5 (1.8–98) | 54.2 (5.8–88) |
| Time to onset (days) | 24 (0–7045) | 39 (0–11463) |
| Injury type | ||
| Cholestatic | 187 (23.9) | 90 (29.3) |
| Mixed | 164 (20.9) | 64 (20.8) |
| Hepatocellular | 256 (32.7) | 139 (45.3) |
| Unknown/unclassified | 176 (22.5) | 14 (4.6) |
| Severity | ||
| Mild | 105 (13.4) | 50 (16.3) |
| Moderate | 80 (10.2) | 62 (20.2) |
| Moderate (hospitalized) | 124 (15.8) | 48 (15.6) |
| Severe | 47 (6.0) | 32 (10.4) |
| Fatal | 20 (2.6) | 16 (5.2) |
| Unknown/unclassified | 407 (52.0) | 99 (32.2) |
| Causality score | ||
| ‘Unlikely’ or ‘possible’ | 83 (10.6) | 35 (11.4) |
| ‘Probable’, ‘very likely’, ‘definite’ | 622 (79.4) | 173 (56.4) |
| Unknown/unclassified | 78 (10.0) | 99 (32.2) |
| Immunoallergic features | ||
| Eosinophilia | 46 (5.9) | NA |
| Fever | 161 (20.6) | NA |
| Rash | 125 (16.0) | NA |
| Any of above | 256 (32.7) | NA |